Correction: Mechanochemical enzymatic resolution of N-benzylated-β³-amino esters

• Mario Pérez-Venegas,
• Gloria Reyes-Rangel,
• Adrián Neri,
• Jaime Escalante and
• Eusebio Juaristi

Beilstein J. Org. Chem. 2017, 13, 2128–2130, doi:10.3762/bjoc.13.210

• . Universidad 1001, Cuernavaca, Morelos, 62210, Mexico El Colegio Nacional, Luis Gonzáles Obregón 23, Centro Histórico, Ciudad de México, 06020, Mexico 10.3762/bjoc.13.210 Keywords: ball-milling; β3-amino acid; Candida antarctica lipase B; enzymatic resolution; mechanochemistry; The original published Tables

Mechanochemical enzymatic resolution of N-benzylated-β³-amino esters

• Mario Pérez-Venegas,
• Gloria Reyes-Rangel,
• Adrián Neri,
• Jaime Escalante and
• Eusebio Juaristi

Beilstein J. Org. Chem. 2017, 13, 1728–1734, doi:10.3762/bjoc.13.167

• resolution of racemic β3-amino esters employing Candida antarctica lipase B (CALB) to afford highly valuable enantioenriched N-benzylated-β3-amino acids in good yields. Furthermore the present protocol is readily scalable. Keywords: ball-milling; β3-amino acid; Candida antarctica lipase B; enzymatic

• report, which is in line with our continuous interest in developing new sustainable organocatalytic protocols [39][49][50][51], and taking advantage of previous experience with the enzymatic hydrolysis of a racemic mixture of N-protected-β3-amino acid methyl esters [52], we decided to examine the use of

• enantioenriched (R)-N-benzylated-β3-amino acid (R)-2a was observed, recovering 51% of enantioenriched starting material. It could be established by chiral HPLC that the ee of the product amounted 80% (Table 1, entry 1). This assay demonstrated that enzymatic hydrolysis can indeed be carried out under HSBM

Molecular architecture with carbohydrate functionalized β-peptides adopting 3₁₄-helical conformation

• Nitin J. Pawar,
• Navdeep S. Sidhu,
• George M. Sheldrick,
• Dilip D. Dhavale and
• Ulf Diederichsen

Beilstein J. Org. Chem. 2014, 10, 948–955, doi:10.3762/bjoc.10.93

• ]. Thus, preparation of the glucose derived β3-amino acid, the corresponding starting material ethyl (methyl 2,3,4-tri-O-benzyl-6,7-dideoxy-α-D-gluco-oct-6-enopyranoside)uronate (9a) was prepared from D-glucose as reported earlier [54]. Conjugate addition of ammonia to the α,β-unsaturated ester 9a